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Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription. implications for Cockayne syndrome.

Cell | Jun 28, 2002

http://www.ncbi.nlm.nih.gov/pubmed/12110180

In addition to xeroderma pigmentosum, mutations in the human XPG gene cause early onset Cockayne syndrome (CS). Here, we provide evidence for the involvement of RAD2, the S. cerevisiae counterpart of XPG, in promoting efficient RNA polymerase II transcription. Inactivation of RAD26, the S. cerevisiae counterpart of the human CSB gene, also causes a deficiency in transcription, and a synergistic decline in transcription occurs in the absence of both the RAD2 and RAD26 genes. Growth is also retarded in the rad2 Delta and rad26 Delta single mutant strains, and a very severe growth inhibition is seen in the rad2 Delta rad26 Delta double mutant. From these and other observations presented here, we suggest that transcriptional defects are the underlying cause of CS.

Pubmed ID: 12110180 RIS Download

Mesh terms: Cell Cycle Proteins | Cell Division | Cockayne Syndrome | DNA-Binding Proteins | Endodeoxyribonucleases | Endonucleases | Fungal Proteins | Galactose | Gene Expression Regulation, Fungal | Genes, Fungal | Humans | Mutation | Nuclear Proteins | RNA Polymerase II | RNA, Messenger | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Schizosaccharomyces pombe Proteins | Time Factors | Transcription Factors | Transcription Factors, General | Transcription, Genetic | Transcriptional Elongation Factors

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Associated grants

  • Agency: NCI NIH HHS, Id: CA35035
  • Agency: NCI NIH HHS, Id: CA41261

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