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Conserved function for embryonic nodal cilia.

How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.

Pubmed ID: 12097899


  • Essner JJ
  • Vogan KJ
  • Wagner MK
  • Tabin CJ
  • Yost HJ
  • Brueckner M



Publication Data

July 4, 2002

Associated Grants


Mesh Terms

  • Animals
  • Axonemal Dyneins
  • Body Patterning
  • Chick Embryo
  • Cilia
  • Conserved Sequence
  • Dyneins
  • Embryo, Mammalian
  • Embryo, Nonmammalian
  • Gastrula
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Mice
  • Organizers, Embryonic
  • Signal Transduction
  • Vertebrates
  • Xenopus
  • Zebrafish
  • Zebrafish Proteins