Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Conserved function for embryonic nodal cilia.

Nature | Jul 4, 2002

http://www.ncbi.nlm.nih.gov/pubmed/12097899

How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.

Pubmed ID: 12097899 RIS Download

Mesh terms: Animals | Axonemal Dyneins | Body Patterning | Chick Embryo | Cilia | Conserved Sequence | Dyneins | Embryo, Mammalian | Embryo, Nonmammalian | Gastrula | Gene Expression Profiling | Gene Expression Regulation, Developmental | Mice | Organizers, Embryonic | Signal Transduction | Vertebrates | Xenopus | Zebrafish | Zebrafish Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.