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Conserved function for embryonic nodal cilia.

Nature | Jul 4, 2002

How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.

Pubmed ID: 12097899 RIS Download

Mesh terms: Animals | Axonemal Dyneins | Body Patterning | Chick Embryo | Cilia | Conserved Sequence | Dyneins | Embryo, Mammalian | Embryo, Nonmammalian | Gastrula | Gene Expression Profiling | Gene Expression Regulation, Developmental | Mice | Organizers, Embryonic | Signal Transduction | Vertebrates | Xenopus | Zebrafish | Zebrafish Proteins

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