Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

mu-Opioid receptors and limbic responses to aversive emotional stimuli.

http://www.ncbi.nlm.nih.gov/pubmed/12011464

Functional neuroimaging studies implicate limbic and paralimbic activity in emotional responses, but few studies have sought to understand neurochemical mechanisms which modulate these responses. We have used positron emission tomography to measure mu-opioid receptor binding, and cerebral blood flow in the same subjects, and demonstrated that the baseline binding potential and the regional cerebral blood flow in the left inferior temporal pole are functionally related. Higher baseline mu-opioid receptor binding potential was associated with lower regional cerebral blood flow in this region during presentation of emotionally salient stimuli. This is consistent with an inhibitory/anxiolytic role of the endogenous opioid system in limbic regions of the temporal lobe and basal forebrain.

Pubmed ID: 12011464 RIS Download

Mesh terms: Adult | Behavior | Brain | Cerebrovascular Circulation | Emotions | Extremities | Galvanic Skin Response | Humans | Image Processing, Computer-Assisted | Male | Receptors, Opioid, mu | Tomography, Emission-Computed

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

SumsDB (Data, Activation Foci)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.