• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Reduced volume of orbitofrontal cortex in major depression.

BACKGROUND: Functional neuroimaging studies have implicated dysfunction of orbitofrontal cortex in the symptoms of depression, and a recent postmortem study of depressed patients found reduced density of neurons and glia in this area. The purpose of this study was to measure volume of orbitofrontal cortex and other frontal cortical subregions in patients with major depression. METHODS: Magnetic resonance imaging was used to measure volume of the orbitofrontal cortex and other frontal cortical regions in patients with major depression in remission (n = 15) and comparison subjects (n = 20). RESULTS: Patients with depression had a statistically significant 32% smaller medial orbitofrontal (gyrus rectus) cortical volume, without smaller volumes of other frontal regions including anterior cingulate Brodmann's area 24 (subgenual gyrus), anterior cingulate Brodmann's area 32, subcallosal gyrus (Brodmann's area 25), or whole brain volume. The findings were significant after statistically controlling for brain size. CONCLUSIONS: These findings are consistent with smaller orbitofrontal cortical volume in depression.

Pubmed ID: 11958777

Authors

  • Bremner JD
  • Vythilingam M
  • Vermetten E
  • Nazeer A
  • Adil J
  • Khan S
  • Staib LH
  • Charney DS

Journal

Biological psychiatry

Publication Data

February 15, 2002

Associated Grants

None

Mesh Terms

  • Adult
  • Analysis of Variance
  • Depressive Disorder
  • Female
  • Frontal Lobe
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged