• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Human receptors for sweet and umami taste.

The three members of the T1R class of taste-specific G protein-coupled receptors have been hypothesized to function in combination as heterodimeric sweet taste receptors. Here we show that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners. In contrast, human T1R1/T1R3 responds to the umami taste stimulus l-glutamate, and this response is enhanced by 5'-ribonucleotides, a hallmark of umami taste. The ligand specificities of rat T1R2/T1R3 and T1R1/T1R3 correspond to those of their human counterparts. These findings implicate the T1Rs in umami taste and suggest that sweet and umami taste receptors share a common subunit.

Pubmed ID: 11917125


  • Li X
  • Staszewski L
  • Xu H
  • Durick K
  • Zoller M
  • Adler E


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

April 2, 2002

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Animals
  • GTP-Binding Proteins
  • Glutamic Acid
  • Guanosine Monophosphate
  • Humans
  • Inosine Monophosphate
  • Molecular Sequence Data
  • Rats
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Taste
  • Transfection