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Human receptors for sweet and umami taste.

The three members of the T1R class of taste-specific G protein-coupled receptors have been hypothesized to function in combination as heterodimeric sweet taste receptors. Here we show that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners. In contrast, human T1R1/T1R3 responds to the umami taste stimulus l-glutamate, and this response is enhanced by 5'-ribonucleotides, a hallmark of umami taste. The ligand specificities of rat T1R2/T1R3 and T1R1/T1R3 correspond to those of their human counterparts. These findings implicate the T1Rs in umami taste and suggest that sweet and umami taste receptors share a common subunit.

Pubmed ID: 11917125


  • Li X
  • Staszewski L
  • Xu H
  • Durick K
  • Zoller M
  • Adler E


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

April 2, 2002

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Animals
  • GTP-Binding Proteins
  • Glutamic Acid
  • Guanosine Monophosphate
  • Humans
  • Inosine Monophosphate
  • Molecular Sequence Data
  • Rats
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Taste
  • Transfection