We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Role of antigen receptor affinity in T cell-independent antibody responses in vivo.

Nature immunology | Apr 28, 2002

To examine how B cell receptor affinity affects clonal selection in thymus-independent type 2 (TI-2) immune responses, we produced mice with antibodies that showed a 40-fold difference in affinity for the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP). The difference in the responses of high- and low-affinity B cells to NP-Ficoll was only twofold. However, in competition experiments only the high-affinity B cells responded to antigen. CD19 deficiency increased the affinity threshold of TI-2 responses, whereas Lyn deficiency enhanced clonal expansion but abrogated B cell terminal differentiation. Thus, in TI-2 immune responses, large differences in affinity produce only small differences in the intrinsic ability of B cells to respond to antigen, and selection for high-affinity clones is due to clonal competition during the earliest stages of the response.

Pubmed ID: 11896394 RIS Download

Mesh terms: Animals | Antigens, CD | Antigens, CD19 | Antigens, Differentiation, B-Lymphocyte | Apoptosis | B-Lymphocytes | Binding, Competitive | Cell Adhesion Molecules | Cell Division | Gene Targeting | Haptens | Immunoglobulin Heavy Chains | Immunoglobulin Variable Region | Lectins | Mice | Mice, Inbred C57BL | Nitrophenols | Phenylacetates | Receptors, Antigen, B-Cell | Sialic Acid Binding Ig-like Lectin 2 | T-Lymphocytes | src-Family Kinases

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIGMS NIH HHS, Id: GM07739

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.