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Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.


Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.

Pubmed ID: 11861581


  • Davis ES
  • Wille L
  • Chestnut BA
  • Sadler PL
  • Shakes DC
  • Golden A



Publication Data

February 25, 2002

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R15 GM60359-01

Mesh Terms

  • Amino Acid Sequence
  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Caenorhabditis elegans
  • Chromosome Segregation
  • DNA Mutational Analysis
  • Fungal Proteins
  • Ligases
  • Meiosis
  • Molecular Sequence Data
  • Mutation
  • Phosphoproteins
  • Protein Subunits
  • RNA, Double-Stranded
  • Schizosaccharomyces pombe Proteins
  • Sequence Alignment
  • Suppression, Genetic
  • Ubiquitin-Protein Ligase Complexes