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Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.

Genetics | Feb 25, 2002

http://www.ncbi.nlm.nih.gov/pubmed/11861581

Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.

Pubmed ID: 11861581 RIS Download

Mesh terms: Amino Acid Sequence | Anaphase-Promoting Complex-Cyclosome | Animals | Caenorhabditis elegans | Chromosome Segregation | DNA Mutational Analysis | Fungal Proteins | Ligases | Meiosis | Molecular Sequence Data | Mutation | Phosphoproteins | Protein Subunits | RNA, Double-Stranded | Schizosaccharomyces pombe Proteins | Sequence Alignment | Suppression, Genetic | Ubiquitin-Protein Ligase Complexes

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Associated grants

  • Agency: NIGMS NIH HHS, Id: R15 GM60359-01

GO (Data, Gene Annotation)

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