• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


DREAM is a critical transcriptional repressor for pain modulation.

Control and treatment of chronic pain remain major clinical challenges. Progress may be facilitated by a greater understanding of the mechanisms underlying pain processing. Here we show that the calcium-sensing protein DREAM is a transcriptional repressor involved in modulating pain. dream(-/-) mice displayed markedly reduced responses in models of acute thermal, mechanical, and visceral pain. dream(-/-) mice also exhibited reduced pain behaviors in models of chronic neuropathic and inflammatory pain. However, dream(-/-) mice showed no major defects in motor function or learning and memory. Mice lacking DREAM had elevated levels of prodynorphin mRNA and dynorphin A peptides in the spinal cord, and the reduction of pain behaviors in dream(-/-) mice was mediated through dynorphin-selective kappa (kappa)-opiate receptors. Thus, DREAM appears to be a critical transcriptional repressor in pain processing.

Pubmed ID: 11792319


  • Cheng HY
  • Pitcher GM
  • Laviolette SR
  • Whishaw IQ
  • Tong KI
  • Kockeritz LK
  • Wada T
  • Joza NA
  • Crackower M
  • Goncalves J
  • Sarosi I
  • Woodgett JR
  • Oliveira-dos-Santos AJ
  • Ikura M
  • van der Kooy D
  • Salter MW
  • Penninger JM



Publication Data

January 11, 2002

Associated Grants


Mesh Terms

  • Animals
  • Base Sequence
  • Behavior, Animal
  • Calcium-Binding Proteins
  • Cells, Cultured
  • Consensus Sequence
  • Down-Regulation
  • Enkephalins
  • Heart
  • Hyperalgesia
  • Inflammation
  • Kv Channel-Interacting Proteins
  • Membrane Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neuralgia
  • Neurons
  • Physical Stimulation
  • Presenilin-1
  • Presenilin-2
  • Protein Precursors
  • Proto-Oncogene Proteins c-fos
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Opioid, kappa
  • Repressor Proteins
  • Spinal Cord
  • Stimulation, Chemical
  • Transcription, Genetic