Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Hoxb8 is required for normal grooming behavior in mice.

Neuron | Jan 3, 2002

http://www.ncbi.nlm.nih.gov/pubmed/11779477

Repertoires of grooming behaviors critical to survival are exhibited by most animal species, including humans. Genes that influence this complex behavior are unknown. We report that mice with disruptions of Hoxb8 show, with 100% penetrance, excessive grooming leading to hair removal and lesions. Additionally, these mice excessively groom normal cagemates. We have been unable to detect any skin or PNS abnormalities in Hoxb8 mutants. These observations suggest that the excessive, pathological grooming exhibited by these mice results from CNS abnormalities. Consistent with this interpretation, we demonstrate Hoxb8 expression in regions of the adult mouse CNS previously implicated in the control of grooming. The aberrant behavior observed in Hoxb8 mutants is not unlike that of humans suffering from the OC-spectrum disorder, trichotillomania. Interestingly, Hoxb8 is expressed in regions of the CNS known as the "OCD-circuit."

Pubmed ID: 11779477 RIS Download

Mesh terms: Aging | Alleles | Animals | Animals, Newborn | Behavior, Animal | Bone and Bones | Brain | Brain Chemistry | Disease Models, Animal | Female | Genotype | Grooming | Homeodomain Proteins | Male | Mice | Mice, Knockout | Mice, Neurologic Mutants | Nerve Net | Obsessive-Compulsive Disorder | Phenotype | RNA, Messenger | Skin

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.