We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Negative regulation of toll-like receptor-mediated signaling by Tollip.

Toll-like receptor (TLR)-mediated recognition of pathogens represents one of the most important mechanisms of innate immunity and disease resistance. The adaptor protein Tollip was identified initially as an intermediate in interleukin (IL)-1 signaling. Here we report that Tollip also associates directly with TLR2 and TLR4 and plays an inhibitory role in TLR-mediated cell activation. Inhibition by Tollip is mediated through its ability to potently suppress the activity of IL-1 receptor-associated kinase (IRAK) after TLR activation. In addition, we show for the first time that Tollip is a bona fide substrate for IRAK and is phosphorylated by IRAK upon stimulation with lipopolysaccharide or IL-1. Negative regulation of TLR signaling by Tollip may therefore serve to limit the production of proinflammatory mediators during inflammation and infection.

Pubmed ID: 11751856 RIS Download

Mesh terms: Carrier Proteins | Cell Line | Dose-Response Relationship, Drug | Drosophila Proteins | Escherichia coli | Humans | Immunoblotting | Interleukin-1 | Interleukin-1 Receptor-Associated Kinases | Intracellular Signaling Peptides and Proteins | Lipopolysaccharides | Membrane Glycoproteins | Phosphorylation | Plasmids | Precipitin Tests | Protein Binding | Protein Kinases | Protein Structure, Tertiary | Receptors, Cell Surface | Signal Transduction | Time Factors | Toll-Like Receptor 2 | Toll-Like Receptor 4 | Toll-Like Receptors

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIAID NIH HHS, Id: R37 AI033443
  • Agency: NIAID NIH HHS, Id: R37 AI 33443

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.