Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Reward circuitry activation by noxious thermal stimuli.

Using functional magnetic resonance imaging (fMRI), we observed that noxious thermal stimuli (46 degrees C) produce significant signal change in putative reward circuitry as well as in classic pain circuitry. Increases in signal were observed in the sublenticular extended amygdala of the basal forebrain (SLEA) and the ventral tegmentum/periaqueductal gray (VT/PAG), while foci of increased signal and decreased signal were observed in the ventral striatum and nucleus accumbens (NAc). Early and late phases were observed for signals in most brain regions, with early activation in reward related regions such as the SLEA, VT/PAG, and ventral striatum. In contrast, structures associated with somatosensory perception, including SI somatosensory cortex, thalamus, and insula, showed delayed activation. These data support the notion that there may be a shared neural system for evaluation of aversive and rewarding stimuli.

Pubmed ID: 11738036


  • Becerra L
  • Breiter HC
  • Wise R
  • Gonzalez RG
  • Borsook D



Publication Data

December 6, 2001

Associated Grants

  • Agency: PHS HHS, Id: 00265
  • Agency: PHS HHS, Id: 01258
  • Agency: PHS HHS, Id: 034626
  • Agency: PHS HHS, Id: 09467
  • Agency: PHS HHS, Id: 13650

Mesh Terms

  • Adult
  • Brain
  • Brain Mapping
  • Electric Stimulation
  • Hot Temperature
  • Humans
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Neural Pathways
  • Pain
  • Prospective Studies
  • Reward
  • Statistics, Nonparametric