Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Caspase-10 is an initiator caspase in death receptor signaling.

A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-receptor-mediated apoptosis. Moreover, Fas crosslinking in primary human T cells leads to the recruitment and activation of caspase-10. Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of FADD. Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially distinct roles in death receptor signaling or other cellular processes.

Pubmed ID: 11717445


  • Wang J
  • Chun HJ
  • Wong W
  • Spencer DM
  • Lenardo MJ


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

November 20, 2001

Associated Grants


Mesh Terms

  • Adaptor Proteins, Signal Transducing
  • Antigens, CD95
  • Apoptosis
  • Apoptosis Regulatory Proteins
  • B-Lymphocytes
  • Carrier Proteins
  • Caspase 10
  • Caspase 8
  • Caspase 9
  • Caspases
  • Cells, Cultured
  • Dendritic Cells
  • Dimerization
  • Enzyme Activation
  • Fas-Associated Death Domain Protein
  • Gene Expression Profiling
  • Humans
  • Jurkat Cells
  • Membrane Glycoproteins
  • Signal Transduction
  • T-Lymphocytes
  • TNF-Related Apoptosis-Inducing Ligand
  • Tumor Necrosis Factor-alpha