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Lack of acrosome formation in Hrb-deficient mice.

The sperm acrosome is essential for sperm-egg fusion and is often defective in men with nonobstructive infertility. Here we report that male mice with a null mutation in Hrb are infertile and display round-headed spermatozoa that lack an acrosome. In wild-type spermatids, Hrb is associated with the cytosolic surface of proacrosomic transport vesicles that fuse to create a single large acrosomic vesicle at step 3 of spermiogenesis. Although proacrosomic vesicles form in spermatids that lack Hrb, the vesicles are unable to fuse, blocking acrosome development at step 2. We conclude that Hrb is required for docking and/or fusion of proacrosomic vesicles during acrosome biogenesis.

Pubmed ID: 11711676


  • Kang-Decker N
  • Mantchev GT
  • Juneja SC
  • McNiven MA
  • van Deursen JM


Science (New York, N.Y.)

Publication Data

November 16, 2001

Associated Grants


Mesh Terms

  • Acrosome
  • Adaptor Protein Complex alpha Subunits
  • Adaptor Proteins, Signal Transducing
  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Calcium-Binding Proteins
  • Carrier Proteins
  • Female
  • Fertilization in Vitro
  • Gene Targeting
  • Golgi Apparatus
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Microscopy, Confocal
  • Microscopy, Electron
  • Microscopy, Immunoelectron
  • Mutation
  • Nuclear Pore Complex Proteins
  • Phosphoproteins
  • RNA-Binding Proteins
  • Sperm Count
  • Sperm Motility
  • Sperm-Ovum Interactions
  • Spermatids
  • Spermatogenesis
  • Spermatozoa
  • Transport Vesicles