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Lack of acrosome formation in Hrb-deficient mice.

Science (New York, N.Y.) | Nov 16, 2001

The sperm acrosome is essential for sperm-egg fusion and is often defective in men with nonobstructive infertility. Here we report that male mice with a null mutation in Hrb are infertile and display round-headed spermatozoa that lack an acrosome. In wild-type spermatids, Hrb is associated with the cytosolic surface of proacrosomic transport vesicles that fuse to create a single large acrosomic vesicle at step 3 of spermiogenesis. Although proacrosomic vesicles form in spermatids that lack Hrb, the vesicles are unable to fuse, blocking acrosome development at step 2. We conclude that Hrb is required for docking and/or fusion of proacrosomic vesicles during acrosome biogenesis.

Pubmed ID: 11711676 RIS Download

Mesh terms: Acrosome | Adaptor Protein Complex alpha Subunits | Adaptor Proteins, Signal Transducing | Adaptor Proteins, Vesicular Transport | Animals | Calcium-Binding Proteins | Carrier Proteins | Female | Fertilization in Vitro | Gene Targeting | Golgi Apparatus | Intracellular Signaling Peptides and Proteins | Male | Membrane Proteins | Mice | Mice, Knockout | Microscopy, Confocal | Microscopy, Electron | Microscopy, Immunoelectron | Mutation | Nuclear Pore Complex Proteins | Phosphoproteins | RNA-Binding Proteins | Sperm Count | Sperm Motility | Sperm-Ovum Interactions | Spermatids | Spermatogenesis | Spermatozoa | Transport Vesicles

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Associated grants


Mouse Genome Informatics (Data, Gene Annotation)

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