Literature search services are currently unavailable. During our hosting provider's UPS upgrade we experienced a hardware failure and are currently working to resolve the issue.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Lack of acrosome formation in Hrb-deficient mice.

The sperm acrosome is essential for sperm-egg fusion and is often defective in men with nonobstructive infertility. Here we report that male mice with a null mutation in Hrb are infertile and display round-headed spermatozoa that lack an acrosome. In wild-type spermatids, Hrb is associated with the cytosolic surface of proacrosomic transport vesicles that fuse to create a single large acrosomic vesicle at step 3 of spermiogenesis. Although proacrosomic vesicles form in spermatids that lack Hrb, the vesicles are unable to fuse, blocking acrosome development at step 2. We conclude that Hrb is required for docking and/or fusion of proacrosomic vesicles during acrosome biogenesis.

Pubmed ID: 11711676


  • Kang-Decker N
  • Mantchev GT
  • Juneja SC
  • McNiven MA
  • van Deursen JM


Science (New York, N.Y.)

Publication Data

November 16, 2001

Associated Grants


Mesh Terms

  • Acrosome
  • Adaptor Protein Complex alpha Subunits
  • Adaptor Proteins, Signal Transducing
  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Calcium-Binding Proteins
  • Carrier Proteins
  • Female
  • Fertilization in Vitro
  • Gene Targeting
  • Golgi Apparatus
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Microscopy, Confocal
  • Microscopy, Electron
  • Microscopy, Immunoelectron
  • Mutation
  • Nuclear Pore Complex Proteins
  • Phosphoproteins
  • RNA-Binding Proteins
  • Sperm Count
  • Sperm Motility
  • Sperm-Ovum Interactions
  • Spermatids
  • Spermatogenesis
  • Spermatozoa
  • Transport Vesicles