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Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation.

OBJECTIVE: The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD. METHOD: Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging at a 4-T field strength. RESULTS: PTSD subjects showed significantly less activation of the thalamus, the anterior cingulate gyrus (Brodmann's area 32), and the medial frontal gyrus (Brodmann's area 10/11) than did the comparison subjects. CONCLUSIONS: The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.

Pubmed ID: 11691703


  • Lanius RA
  • Williamson PC
  • Densmore M
  • Boksman K
  • Gupta MA
  • Neufeld RW
  • Gati JS
  • Menon RS


The American journal of psychiatry

Publication Data

November 5, 2001

Associated Grants


Mesh Terms

  • Adult
  • Brain
  • Comorbidity
  • Depressive Disorder, Major
  • Dysthymic Disorder
  • Female
  • Heart Rate
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory
  • Panic Disorder
  • Prevalence
  • Stress Disorders, Post-Traumatic
  • Substance-Related Disorders