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Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation.

OBJECTIVE: The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD. METHOD: Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging at a 4-T field strength. RESULTS: PTSD subjects showed significantly less activation of the thalamus, the anterior cingulate gyrus (Brodmann's area 32), and the medial frontal gyrus (Brodmann's area 10/11) than did the comparison subjects. CONCLUSIONS: The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.

Pubmed ID: 11691703 RIS Download

Mesh terms: Adult | Brain | Comorbidity | Depressive Disorder, Major | Dysthymic Disorder | Female | Heart Rate | Humans | Magnetic Resonance Imaging | Male | Memory | Panic Disorder | Prevalence | Stress Disorders, Post-Traumatic | Substance-Related Disorders