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The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition.

Snail family genes encode DNA binding zinc finger proteins that act as transcriptional repressors. Mouse embryos deficient for the Snail (Sna) gene exhibit defects in the formation of the mesoderm germ layer. In Sna(-/-) mutant embryos, a mesoderm layer forms and mesodermal marker genes are induced but the mutant mesoderm is morphologically abnormal. Lacunae form within the mesoderm layer of the mutant embryos, and cells lining these lacunae retain epithelial characteristics. These cells resemble a columnar epithelium and have apical-basal polarity, with microvilli along the apical surface and intercellular electron-dense adhesive junctions that resemble adherens junctions. E-cadherin expression is retained in the mesoderm of the Sna(-/-) embryos. These defects are strikingly similar to the gastrulation defects observed in snail-deficient Drosophila embryos, suggesting that the mechanism of repression of E-cadherin transcription by Snail family proteins may have been present in the metazoan ancestor of the arthropod and mammalian lineages.

Pubmed ID: 11689706 RIS Download

Mesh terms: Abnormalities, Multiple | Adherens Junctions | Animals | Cadherins | DNA-Binding Proteins | Embryo Loss | Embryo, Mammalian | Epithelium | Gene Targeting | Mesoderm | Mice | Mice, Knockout | Mice, Mutant Strains | Phenotype | RNA, Messenger | Snail Family Transcription Factors | Transcription Factors | Zinc Fingers

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Associated grants

  • Agency: NCI NIH HHS, Id: CA09217
  • Agency: NICHD NIH HHS, Id: HD34883
  • Agency: NICHD NIH HHS, Id: R01 HD034883
  • Agency: NCI NIH HHS, Id: P30 CA034196
  • Agency: NCI NIH HHS, Id: T32 CA009217
  • Agency: NIDCR NIH HHS, Id: P60 DE013078
  • Agency: NIDCR NIH HHS, Id: DE13078
  • Agency: NCI NIH HHS, Id: CA34196

Mouse Genome Informatics (Data, Gene Annotation)

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