Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development.

http://www.ncbi.nlm.nih.gov/pubmed/11688560

SALL1 is a mammalian homolog of the Drosophila region-specific homeotic gene spalt (sal); heterozygous mutations in SALL1 in humans lead to Townes-Brocks syndrome. We have isolated a mouse homolog of SALL1 (Sall1) and found that mice deficient in Sall1 die in the perinatal period and that kidney agenesis or severe dysgenesis are present. Sall1 is expressed in the metanephric mesenchyme surrounding ureteric bud; homozygous deletion of Sall1 results in an incomplete ureteric bud outgrowth, a failure of tubule formation in the mesenchyme and an apoptosis of the mesenchyme. This phenotype is likely to be primarily caused by the absence of the inductive signal from the ureter, as the Sall1-deficient mesenchyme is competent with respect to epithelial differentiation. Sall1 is therefore essential for ureteric bud invasion, the initial key step for metanephros development.

Pubmed ID: 11688560 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Cloning, Molecular | Crosses, Genetic | Down-Regulation | Gene Expression Regulation, Developmental | Genetic Markers | Heterozygote | Humans | In Situ Hybridization | Kidney | Mesoderm | Mice | Mice, Inbred C57BL | Models, Genetic | Molecular Sequence Data | Mutation | Phenotype | Polymerase Chain Reaction | Sequence Homology, Amino Acid | Transcription Factors | Ureter

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.