Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Identification of ubiquitin ligases required for skeletal muscle atrophy.

Science (New York, N.Y.) | Nov 23, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11679633

Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models. Two of these genes encode ubiquitin ligases: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box (MAFbx), the latter being a member of the SCF family of E3 ubiquitin ligases. Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy.

Pubmed ID: 11679633 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Cloning, Molecular | Creatine Kinase | Creatine Kinase, MM Form | DNA-Binding Proteins | Gene Deletion | Gene Expression Profiling | Hindlimb Suspension | Humans | Immobilization | Isoenzymes | Mice | Mice, Knockout | Molecular Sequence Data | Muscle Denervation | Muscle Proteins | Muscle, Skeletal | Muscular Atrophy | MyoD Protein | Myogenic Regulatory Factor 5 | Myogenin | Peptide Synthases | Phenotype | Protein Binding | RNA, Messenger | Rats | Rats, Sprague-Dawley | SKP Cullin F-Box Protein Ligases | Trans-Activators | Up-Regulation

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.