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HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues.

Although HIV-1 gene expression is detected in naive, resting T cells in vivo, such cells are resistant to productive infection in vitro. However, we found that the endogenous microenvironment of human lymphoid tissues supports de novo infection and depletion of this population. Cell cycle analysis and DNA labeling experiments established that these cells were definitively quiescent and thus infected de novo. Quantitation of the "burst size" within naive cells further demonstrated that these cells were productively infected and contributed to the local viral burden. These findings demonstrate that lymphoid tissues support active HIV-1 replication in resting, naive T cells. Moreover, these cells are not solely reservoirs of latent virus but are permissive hosts for viral replication that likely targets them for elimination.

Pubmed ID: 11672548

Authors

  • Eckstein DA
  • Penn ML
  • Korin YD
  • Scripture-Adams DD
  • Zack JA
  • Kreisberg JF
  • Roederer M
  • Sherman MP
  • Chin PS
  • Goldsmith MA

Journal

Immunity

Publication Data

October 23, 2001

Associated Grants

  • Agency: NIAID NIH HHS, Id: R01-AI36554
  • Agency: NIAID NIH HHS, Id: R01-AI43695
  • Agency: NIAID NIH HHS, Id: R37-AI36059
  • Agency: NIDCR NIH HHS, Id: T32-DEO7296

Mesh Terms

  • CD4-Positive T-Lymphocytes
  • Cell Cycle
  • Cells, Cultured
  • HIV-1
  • Humans
  • Immunologic Memory
  • Lymphocyte Activation
  • Lymphocyte Depletion
  • Lymphoid Tissue
  • Palatine Tonsil
  • Virus Replication