Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis.

Oncogene | Oct 4, 2001

The lats gene encodes a family of proteins conserved from insects to humans. Drosophila carrying lats mutant cells or mice deficient for Lats1 develop tumors in various tissues. The mammalian LATS1 protein was previously shown to bind to CDC2, suggesting that LATS1 may modulate G(2)/M cell cycle progression by affecting CDC2 activity. In this study, we introduced human LATS1 into LATS(-/-) MEF cells by adenovirus-mediated gene transfer. Overexpression of LATS1 causes G(2)/M arrest through inhibition of CDC2 kinase activity. Furthermore, overexpression of LATS1 significantly suppressed the human tumor cell growth in vitro and tumorigenicity in vivo by inducing either cell cycle arrest in G(2)/M or apoptosis. These observations suggest that LATS1 is a potent growth suppressor and, like other tumor suppressors, it suppresses growth by inducing cell cycle arrest or apoptosis.

Pubmed ID: 11641775 RIS Download

Mesh terms: Adenoviridae | Animals | Apoptosis | CDC2 Protein Kinase | Cell Division | Cells, Cultured | Cyclin B | Drosophila | Drosophila Proteins | Fibroblasts | G2 Phase | Gene Deletion | Genetic Vectors | Humans | Mice | Mitosis | Neoplasms | Protein Kinases | Protein-Serine-Threonine Kinases | Transfection | Tumor Cells, Cultured