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Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1).

Neuropharmacology | Nov 19, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11640934

Previous results have suggested that the Ras signaling pathway is involved in learning and memory. Ras is activated by nucleotide exchange factors, such as the calmodulin-activated guanine-nucleotide releasing factor 1 (Ras-GRF1). To test whether Ras-GRF1 is required for learning and memory, we inactivated the Ras-GRF1 gene in mice. These mutants performed normally in a rota-rod motor coordination task, and in two amygdala-dependent tasks (inhibitory avoidance and contextual conditioning). In contrast the mutants were impaired in three hippocampus-dependent learning tasks: contextual discrimination, the social transmission of food preferences, and the hidden-platform version of the Morris water maze. These studies indicate that Ras-GRF1 plays a role in hippocampal-dependent learning and memory.

Pubmed ID: 11640934 RIS Download

Mesh terms: Amygdala | Animals | Avoidance Learning | Conditioning (Psychology) | Crosses, Genetic | Female | Food Preferences | Hippocampus | Learning | Male | Maze Learning | Memory | Mice | Mice, Inbred C57BL | Mice, Knockout | Motor Activity | Social Behavior | ras-GRF1

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Associated grants

  • Agency: NINDS NIH HHS, Id: NS38480

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