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Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1).

Previous results have suggested that the Ras signaling pathway is involved in learning and memory. Ras is activated by nucleotide exchange factors, such as the calmodulin-activated guanine-nucleotide releasing factor 1 (Ras-GRF1). To test whether Ras-GRF1 is required for learning and memory, we inactivated the Ras-GRF1 gene in mice. These mutants performed normally in a rota-rod motor coordination task, and in two amygdala-dependent tasks (inhibitory avoidance and contextual conditioning). In contrast the mutants were impaired in three hippocampus-dependent learning tasks: contextual discrimination, the social transmission of food preferences, and the hidden-platform version of the Morris water maze. These studies indicate that Ras-GRF1 plays a role in hippocampal-dependent learning and memory.

Pubmed ID: 11640934


  • Giese KP
  • Friedman E
  • Telliez JB
  • Fedorov NB
  • Wines M
  • Feig LA
  • Silva AJ



Publication Data

November 19, 2001

Associated Grants

  • Agency: NINDS NIH HHS, Id: NS38480

Mesh Terms

  • Amygdala
  • Animals
  • Avoidance Learning
  • Conditioning (Psychology)
  • Crosses, Genetic
  • Female
  • Food Preferences
  • Hippocampus
  • Learning
  • Male
  • Maze Learning
  • Memory
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Motor Activity
  • Social Behavior
  • ras-GRF1