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Coupling of the TCR to integrin activation by Slap-130/Fyb.

SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.

Pubmed ID: 11567141

Authors

  • Peterson EJ
  • Woods ML
  • Dmowski SA
  • Derimanov G
  • Jordan MS
  • Wu JN
  • Myung PS
  • Liu QH
  • Pribila JT
  • Freedman BD
  • Shimizu Y
  • Koretzky GA

Journal

Science (New York, N.Y.)

Publication Data

September 21, 2001

Associated Grants

  • Agency: NIAID NIH HHS, Id: R01 AI060921

Mesh Terms

  • Actins
  • Adaptor Proteins, Signal Transducing
  • Animals
  • Antigens, CD
  • Antigens, CD3
  • Antigens, Differentiation, T-Lymphocyte
  • Carrier Proteins
  • Cell Adhesion
  • Cell Membrane
  • Immunologic Capping
  • Intercellular Adhesion Molecule-1
  • Interleukin-2
  • Lectins, C-Type
  • Lymphocyte Activation
  • Lymphocyte Function-Associated Antigen-1
  • Mice
  • Phosphatidylinositol 3-Kinases
  • Phosphoproteins
  • Protein-Tyrosine Kinases
  • Receptors, Antigen, T-Cell
  • Receptors, Interleukin-2
  • Signal Transduction
  • T-Lymphocytes