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Coupling of the TCR to integrin activation by Slap-130/Fyb.

Science (New York, N.Y.) | Sep 21, 2001

SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.

Pubmed ID: 11567141 RIS Download

Mesh terms: Actins | Adaptor Proteins, Signal Transducing | Animals | Antigens, CD | Antigens, CD3 | Antigens, Differentiation, T-Lymphocyte | Carrier Proteins | Cell Adhesion | Cell Membrane | Immunologic Capping | Intercellular Adhesion Molecule-1 | Interleukin-2 | Lectins, C-Type | Lymphocyte Activation | Lymphocyte Function-Associated Antigen-1 | Mice | Phosphatidylinositol 3-Kinases | Phosphoproteins | Protein-Tyrosine Kinases | Receptors, Antigen, T-Cell | Receptors, Interleukin-2 | Signal Transduction | T-Lymphocytes

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Associated grants

  • Agency: NIAID NIH HHS, Id: R01 AI060921

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