We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

MEN2A-RET-induced cellular transformation by activation of STAT3.

Oncogene | Aug 30, 2001

The MEN2A oncogene encodes for a constitutive active member of the RET receptor tyrosine kinase family. Here, we report that MEN2A-RET activates Signal Transducer and Activator of Transcription 3 (STAT3) via two YxxV/Q STAT3 docking sites, Tyr752 and Tyr928. MEN2A-RET induces both Tyr705 and Ser727 phosphorylation of STAT3, and STAT3 serine phosphorylation is required for its maximal transcriptional activity. Stable NIH3T3 cell lines expressing both MEN2A-RET and STAT3alpha but not STAT3beta, are characterized by enhanced proliferation and cyclin-D1 promoter activity, and enhanced growth in soft agar. These data indicate that malignant cell growth induced by MEN2A-RET involves its activation of STAT3.

Pubmed ID: 11536047 RIS Download

Mesh terms: 3T3 Cells | Animals | Binding Sites | COS Cells | Cell Division | Cell Line | Cell Transformation, Neoplastic | DNA-Binding Proteins | Dose-Response Relationship, Drug | Drosophila Proteins | Enzyme Activation | Genes, Reporter | Humans | Mice | Multiple Endocrine Neoplasia Type 2a | Oncogenes | Phosphorylation | Precipitin Tests | Protein Binding | Protein Structure, Tertiary | Proto-Oncogene Proteins | Proto-Oncogene Proteins c-ret | Receptor Protein-Tyrosine Kinases | STAT3 Transcription Factor | Serine | Time Factors | Trans-Activators | Transcriptional Activation | Transfection | Tyrosine | Up-Regulation