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Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice.

Both ionotropic and metabotropic glutamate receptors (mGluRs) are involved in the behavioral effects of pyschostimulants; however, the specific contributions of individual mGluR subtypes remain unknown. Here we show that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA) levels similar to wild-type (WT) mice. These results demonstrate a significant contribution of mGlu5 receptors to the behavioral effects of cocaine, and suggest that they may be involved in cocaine addiction.

Pubmed ID: 11528416


  • Chiamulera C
  • Epping-Jordan MP
  • Zocchi A
  • Marcon C
  • Cottiny C
  • Tacconi S
  • Corsi M
  • Orzi F
  • Conquet F


Nature neuroscience

Publication Data

September 30, 2001

Associated Grants


Mesh Terms

  • Animals
  • Cocaine
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Motor Activity
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate
  • Reference Values
  • Reinforcement (Psychology)
  • Self Administration