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Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice.

Nature neuroscience | Sep 30, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11528416

Both ionotropic and metabotropic glutamate receptors (mGluRs) are involved in the behavioral effects of pyschostimulants; however, the specific contributions of individual mGluR subtypes remain unknown. Here we show that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA) levels similar to wild-type (WT) mice. These results demonstrate a significant contribution of mGlu5 receptors to the behavioral effects of cocaine, and suggest that they may be involved in cocaine addiction.

Pubmed ID: 11528416 RIS Download

Mesh terms: Animals | Cocaine | Mice | Mice, Inbred C57BL | Mice, Knockout | Motor Activity | Receptor, Metabotropic Glutamate 5 | Receptors, Metabotropic Glutamate | Reference Values | Reinforcement (Psychology) | Self Administration

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