• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Deletion of a coordinate regulator of type 2 cytokine expression in mice.

Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice. The capacity to develop T(H)2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1(-/-) mice maintained their capacity to produce interleukin 4. A T cell-specific element critical for the optimal expression of type 2 cytokines may represent the evolution of a regulatory sequence exploited by adaptive immunity.

Pubmed ID: 11526400


  • Mohrs M
  • Blankespoor CM
  • Wang ZE
  • Loots GG
  • Afzal V
  • Hadeiba H
  • Shinkai K
  • Rubin EM
  • Locksley RM


Nature immunology

Publication Data

September 29, 2001

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI30663
  • Agency: NIGMS NIH HHS, Id: GM07618
  • Agency: NHLBI NIH HHS, Id: HL56385
  • Agency: NHLBI NIH HHS, Id: HL66671

Mesh Terms

  • Animals
  • Aspergillosis
  • Cells, Cultured
  • Conserved Sequence
  • Cytokines
  • DNA, Intergenic
  • Gene Targeting
  • Interleukin-4
  • Leishmaniasis, Cutaneous
  • Mast Cells
  • Mice
  • Mice, Knockout
  • RNA, Messenger
  • Sequence Deletion
  • Strongylida Infections
  • Th2 Cells