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Deletion of a coordinate regulator of type 2 cytokine expression in mice.

Nature immunology | Sep 29, 2001

Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice. The capacity to develop T(H)2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1(-/-) mice maintained their capacity to produce interleukin 4. A T cell-specific element critical for the optimal expression of type 2 cytokines may represent the evolution of a regulatory sequence exploited by adaptive immunity.

Pubmed ID: 11526400 RIS Download

Mesh terms: Animals | Aspergillosis | Cells, Cultured | Conserved Sequence | Cytokines | DNA, Intergenic | Gene Targeting | Interleukin-4 | Leishmaniasis, Cutaneous | Mast Cells | Mice | Mice, Knockout | RNA, Messenger | Sequence Deletion | Strongylida Infections | Th2 Cells

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Associated grants

  • Agency: NIAID NIH HHS, Id: AI30663
  • Agency: NIGMS NIH HHS, Id: GM07618
  • Agency: NHLBI NIH HHS, Id: HL56385
  • Agency: NHLBI NIH HHS, Id: HL66671

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