Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny.

Cell | Aug 24, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11525736

Neural precursors often generate distinct cell types in a specific order, but the intrinsic or extrinsic cues regulating the timing of cell fate specification are poorly understood. Here we show that Drosophila neural precursors (neuroblasts) sequentially express the transcription factors Hunchback --> Krüppel --> Pdm --> Castor, with differentiated progeny maintaining the transcription factor profile present at their birth. Hunchback is necessary and sufficient for first-born cell fates, whereas Krüppel is necessary and sufficient for second-born cell fates; this is observed in multiple lineages and is independent of the cell type involved. We propose that Hunchback and Krüppel control early-born temporal identity in neuroblast cell lineages.

Pubmed ID: 11525736 RIS Download

Mesh terms: Animals | Cell Lineage | DNA-Binding Proteins | Drosophila Proteins | Drosophila melanogaster | Gene Expression Regulation | Homeodomain Proteins | Insect Proteins | Juvenile Hormones | Kruppel-Like Transcription Factors | Morphogenesis | Neurons | POU Domain Factors | Repressor Proteins | Time Factors | Transcription Factors

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NICHD NIH HHS, Id: HD27056

FLYBASE (Data, Gene Expression)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.