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An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.

Science (New York, N.Y.) | Sep 14, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11509691

The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

Pubmed ID: 11509691 RIS Download

Mesh terms: Animals | Antigens, CD | B-Cell Activating Factor | B-Cell Maturation Antigen | B-Lymphocyte Subsets | B-Lymphocytes | Bone Marrow Cells | Cell Separation | Cell Survival | Flow Cytometry | Immunoglobulins | Leukopoiesis | Lymph Nodes | Lymphocyte Count | Lymphoid Tissue | Membrane Proteins | Mice | Mice, Inbred A | Mice, Knockout | Phenotype | Receptors, Tumor Necrosis Factor | Signal Transduction | Spleen | Thymus Gland | Tumor Necrosis Factor-alpha

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