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An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.

The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

Pubmed ID: 11509691

Authors

  • Schiemann B
  • Gommerman JL
  • Vora K
  • Cachero TG
  • Shulga-Morskaya S
  • Dobles M
  • Frew E
  • Scott ML

Journal

Science (New York, N.Y.)

Publication Data

September 14, 2001

Associated Grants

None

Mesh Terms

  • Animals
  • Antigens, CD
  • B-Cell Activating Factor
  • B-Cell Maturation Antigen
  • B-Lymphocyte Subsets
  • B-Lymphocytes
  • Bone Marrow Cells
  • Cell Separation
  • Cell Survival
  • Flow Cytometry
  • Immunoglobulins
  • Leukopoiesis
  • Lymph Nodes
  • Lymphocyte Count
  • Lymphoid Tissue
  • Membrane Proteins
  • Mice
  • Mice, Inbred A
  • Mice, Knockout
  • Phenotype
  • Receptors, Tumor Necrosis Factor
  • Signal Transduction
  • Spleen
  • Thymus Gland
  • Tumor Necrosis Factor-alpha