CLAN, a novel human CED-4-like gene.
Proteins governing cell death form the basis of many normal processes and contribute to the pathogenesis of many diseases when dysregulated. Here we report the cloning of a novel human CED-4-like gene, CLAN, and several of its alternatively spliced isoforms. These caspase-associated recruitment domain (CARD)-containing proteins are expressed at varying degrees in normal human tissues and may contribute to a number of intracellular processes including apoptosis, cytokine processing, and NF-kappa B activation. The CARD of the CLAN proteins binds a number of other CARD-containing proteins including caspase-1, BCL10, NOD2, and NAC. Once their physiologic functions are uncovered, CLAN proteins may prove to be valuable therapeutic targets.
Pubmed ID: 11472070 RIS Download
Amino Acid Sequence | Apoptosis | Apoptosis Regulatory Proteins | CARD Signaling Adaptor Proteins | Caenorhabditis elegans Proteins | Calcium-Binding Proteins | Caspases | Chromosomes, Human, Pair 2 | Cloning, Molecular | DNA, Complementary | Electrophoresis, Polyacrylamide Gel | Helminth Proteins | Humans | Models, Genetic | Molecular Sequence Data | NF-kappa B | Nucleic Acid Hybridization | Plasmids | Precipitin Tests | Protein Isoforms | Protein Structure, Tertiary | RNA, Messenger | Reverse Transcriptase Polymerase Chain Reaction | Sequence Homology, Amino Acid | Tissue Distribution