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CLAN, a novel human CED-4-like gene.


Proteins governing cell death form the basis of many normal processes and contribute to the pathogenesis of many diseases when dysregulated. Here we report the cloning of a novel human CED-4-like gene, CLAN, and several of its alternatively spliced isoforms. These caspase-associated recruitment domain (CARD)-containing proteins are expressed at varying degrees in normal human tissues and may contribute to a number of intracellular processes including apoptosis, cytokine processing, and NF-kappa B activation. The CARD of the CLAN proteins binds a number of other CARD-containing proteins including caspase-1, BCL10, NOD2, and NAC. Once their physiologic functions are uncovered, CLAN proteins may prove to be valuable therapeutic targets.

Pubmed ID: 11472070


  • Damiano JS
  • Stehlik C
  • Pio F
  • Godzik A
  • Reed JC



Publication Data

July 26, 2001

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Apoptosis
  • Apoptosis Regulatory Proteins
  • CARD Signaling Adaptor Proteins
  • Caenorhabditis elegans Proteins
  • Calcium-Binding Proteins
  • Caspases
  • Chromosomes, Human, Pair 2
  • Cloning, Molecular
  • DNA, Complementary
  • Electrophoresis, Polyacrylamide Gel
  • Helminth Proteins
  • Humans
  • Models, Genetic
  • Molecular Sequence Data
  • NF-kappa B
  • Nucleic Acid Hybridization
  • Plasmids
  • Precipitin Tests
  • Protein Isoforms
  • Protein Structure, Tertiary
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Homology, Amino Acid
  • Tissue Distribution