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dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.

Molecular cell | Mar 15, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11463372

The synthetic multivulva (synMuv) genes define two functionally redundant pathways that antagonize RTK/Ras signaling during Caenorhabditis elegans vulval induction. The synMuv gene lin-35 encodes a protein similar to the mammalian tumor suppressor pRB and has been proposed to act as a transcriptional repressor. Studies using mammalian cells have shown that pRB can prevent cell cycle progression by inhibiting DP/E2F-mediated transcriptional activation. We identified C. elegans genes that encode proteins similar to DP or E2F. Loss-of-function mutations in two of these genes, dpl-1 DP and efl-1 E2F, caused the same vulval abnormalities as do lin-35 Rb loss-of-function mutations. We propose that rather than being inhibited by lin-35 Rb, dpl-1 DP and efl-1 E2F act with lin-35 Rb in transcriptional repression to antagonize RTK/Ras signaling during vulval development.

Pubmed ID: 11463372 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Animals, Genetically Modified | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Cell Cycle Proteins | Cell Division | Cell Lineage | Cell Nucleus | Cloning, Molecular | DNA-Binding Proteins | E2F Transcription Factors | Female | Gene Deletion | Gene Expression Regulation, Developmental | Genes, Helminth | Helminth Proteins | Membrane Glycoproteins | Molecular Sequence Data | Neurons | Nuclear Proteins | Phenotype | Protein Binding | Repressor Proteins | Signal Transduction | Transcription Factors | Vulva | ras Proteins

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM24663

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