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A DNA damage response pathway controlled by Tel1 and the Mre11 complex.

Molecular cell | Jun 29, 2001

We define a DNA damage checkpoint pathway in S. cerevisiae governed by the ATM homolog Tel1 and the Mre11 complex. In mitotic cells, the Tel1-Mre11 complex pathway triggers Rad53 activation and its interaction with Rad9, whereas in meiosis it acts via Rad9 and the Rad53 paralog Mre4/Mek1. Activation of the Tel1-Mre11 complex pathway checkpoint functions appears to depend upon the Mre11 complex as a damage sensor and, at least in meiotic cells, to depend on unprocessed DNA double-strand breaks (DSBs). The DSB repair functions of the Mre11 complex are enhanced by the pathway, suggesting that the complex both initiates and is regulated by the Tel1-dependent DSB signal. These findings demonstrate that the diverse functions of the Mre11 complex in the cellular DNA damage response are conserved in mammals and yeast.

Pubmed ID: 11430828 RIS Download

Mesh terms: Cell Cycle Proteins | Checkpoint Kinase 2 | DNA Damage | DNA Repair | DNA-Binding Proteins | Endodeoxyribonucleases | Exodeoxyribonucleases | Fungal Proteins | Genes, cdc | Intracellular Signaling Peptides and Proteins | Protein Kinases | Protein-Serine-Threonine Kinases | Saccharomyces cerevisiae Proteins | Yeasts

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