Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors.

FEBS letters | Jun 22, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11423130

Mox1 and Mox2 homeobox genes have been shown to be critical in axial skeleton and in limb muscle development respectively. Pax1 and Pax3 gene products are also implicated in these processes. Mox and Pax expression patterns are highly overlapping both spatially and temporally during embryonic development. We show here for the first time that Mox proteins physically interact with Pax1 and Pax3 using the yeast two-hybrid protein interaction assay as well as in vitro biochemical assays. There is a strong preference of Mox1 to associate with Pax1 rather than Pax3 and of Mox2 to associate with Pax3 rather than Pax1. The observed interactions are mediated through the homeodomain of Mox.

Pubmed ID: 11423130 RIS Download

Mesh terms: Animals | Antigens, CD | Antigens, Surface | DNA-Binding Proteins | Escherichia coli | Genes, Homeobox | Mice | NADH, NADPH Oxidoreductases | NADPH Oxidase | Paired Box Transcription Factors | Recombinant Proteins | Transcription Factors | Two-Hybrid System Techniques

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.