Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.
The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. Here we show that the gamma(c) is also shared with the IL-21R complex. Although IL-21 binds to the IL-21R expressed on gamma(c)-deficient ED40515(-) cells, IL-21 is unable to transduce any intracytoplasmic signals. However, in EDgamma-16 cells, a gamma(c)-transfected ED40515(-) cell line, IL-21 binds to the IL-21R and can activate Janus kinase (JAK)1, JAK3, STAT1, and STAT3. The chemical cross-linking study reveals the direct binding of IL-21 to the gamma(c). These data clearly demonstrate that the gamma(c) is an indispensable subunit of the functional IL-21R complex.
Pubmed ID: 11418623 RIS Download
Cell Line | DNA-Binding Proteins | Enzyme Activation | Humans | Interleukin Receptor Common gamma Subunit | Interleukin-21 Receptor alpha Subunit | Interleukins | Janus Kinase 1 | Janus Kinase 3 | Milk Proteins | Protein Binding | Protein-Tyrosine Kinases | Receptors, Interleukin | Receptors, Interleukin-21 | Receptors, Interleukin-7 | STAT1 Transcription Factor | STAT3 Transcription Factor | STAT5 Transcription Factor | Signal Transduction | Trans-Activators