Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin.

Neuron | May 7, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11395000

Myelinated fibers are organized into distinct domains that are necessary for saltatory conduction. These domains include the nodes of Ranvier and the flanking paranodal regions where glial cells closely appose and form specialized septate-like junctions with axons. These junctions contain a Drosophila Neurexin IV-related protein, Caspr/Paranodin (NCP1). Mice that lack NCP1 exhibit tremor, ataxia, and significant motor paresis. In the absence of NCP1, normal paranodal junctions fail to form, and the organization of the paranodal loops is disrupted. Contactin is undetectable in the paranodes, and K(+) channels are displaced from the juxtaparanodal into the paranodal domains. Loss of NCP1 also results in a severe decrease in peripheral nerve conduction velocity. These results show a critical role for NCP1 in the delineation of specific axonal domains and the axon-glia interactions required for normal saltatory conduction.

Pubmed ID: 11395000 RIS Download

Mesh terms: Aging | Animals | Axons | Cell Adhesion Molecules, Neuronal | Cloning, Molecular | Drosophila | Drosophila Proteins | Female | Genomic Library | Heterozygote | Homozygote | Humans | Male | Membrane Glycoproteins | Membrane Proteins | Mice | Mice, Knockout | Nerve Fibers, Myelinated | Nerve Tissue Proteins | Neuroglia | Neuropeptides | Optic Nerve | Potassium Channels | Receptors, Cell Surface | Restriction Mapping | Sciatic Nerve

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIGMS NIH HHS, Id: 5T32 GM07308
  • Agency: NCI NIH HHS, Id: KO1-CA 78437
  • Agency: NINDS NIH HHS, Id: NS37475
  • Agency: NINDS NIH HHS, Id: NS38208
  • Agency: CSR NIH HHS, Id: RG2539

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.