Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism.

EMBO reports | May 28, 2001

The discoidin domain receptor 2 (DDR2) is a member of a subfamily of receptor tyrosine kinases whose ligands are fibrillar collagens, and is widely expressed in postnatal tissues. We have generated DDR2-deficient mice to establish the in vivo functions of this receptor, which have remained obscure. These mice exhibit dwarfism and shortening of long bones. This phenotype appears to be caused by reduced chondrocyte proliferation, rather than aberrant differentiation or function. In a skin wound healing model, DDR2-/- mice exhibit a reduced proliferative response compared with wild-type littermates. In vitro, fibroblasts derived from DDR2-/- mutants proliferate more slowly than wild-type fibroblasts, a defect that is rescued by introduction of wild-type but not kinase-dead DDR2 receptor. Together our results suggest that DDR2 acts as an extracellular matrix sensor to modulate cell proliferation.

Pubmed ID: 11375938 RIS Download

Mesh terms: Animals | Apoptosis | Bone Development | Cell Division | Chondrocytes | Collagen | Discoidin Domain Receptors | Dwarfism | Fibroblasts | Growth Plate | Humerus | Immunoblotting | In Situ Hybridization | In Situ Nick-End Labeling | Metatarsal Bones | Mice | Mice, Knockout | Receptor Protein-Tyrosine Kinases | Receptors, Mitogen | Skin | Tibia | Wound Healing

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants


Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.