Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Pot1, the putative telomere end-binding protein in fission yeast and humans.

Science (New York, N.Y.) | May 11, 2001

Telomere proteins from ciliated protozoa bind to the single-stranded G-rich DNA extensions at the ends of macronuclear chromosomes. We have now identified homologous proteins in fission yeast and in humans. These Pot1 (protection of telomeres) proteins each bind the G-rich strand of their own telomeric repeat sequence, consistent with a direct role in protecting chromosome ends. Deletion of the fission yeast pot1+ gene has an immediate effect on chromosome stability, causing rapid loss of telomeric DNA and chromosome circularization. It now appears that the protein that caps the ends of chromosomes is widely dispersed throughout the eukaryotic kingdom.

Pubmed ID: 11349150 RIS Download

Mesh terms: Amino Acid Sequence | Base Sequence | Binding Sites | Chromosome Segregation | Chromosomes, Fungal | Cloning, Molecular | DNA | DNA-Binding Proteins | Electrophoresis, Gel, Pulsed-Field | Female | Gene Deletion | Gene Expression Profiling | Heterozygote | Humans | Molecular Sequence Data | Ovary | Phenotype | RNA, Messenger | Schizosaccharomyces | Schizosaccharomyces pombe Proteins | Sequence Alignment | Substrate Specificity | Telomere | Telomere-Binding Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.