Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

A candidate taste receptor gene near a sweet taste locus.

Nature neuroscience | May 25, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11319557

The mechanisms underlying sweet taste in mammals have been elusive. Although numerous studies have implicated G proteins in sweet taste detection, the expected G protein-coupled receptors have not been found. Here we describe a candidate taste receptor gene, T1r3, that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet tastants. T1R3 differs in amino acid sequence in mouse strains with different Sac phenotypes ('tasters' versus 'nontasters'). In addition, a perfect correlation exists between two different T1r3 alleles and Sac phenotypes in recombinant inbred mouse strains. The T1r3 gene is expressed in a subset of taste cells in circumvallate, foliate and fungiform taste papillae. In circumvallate and foliate papillae, most T1r3-expressing cells also express a gene encoding a related receptor, T1R2, raising the possibility that these cells recognize more than one ligand, or that the two receptors function as heterodimers.

Pubmed ID: 11319557 RIS Download

Mesh terms: Alleles | Amino Acid Sequence | Animals | Chemoreceptor Cells | Chromosome Mapping | Cloning, Molecular | DNA | Genes | In Situ Hybridization | Mice | Mice, Inbred Strains | Molecular Sequence Data | Phenotype | Polymorphism, Genetic | Taste | Taste Buds