Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Predictability modulates human brain response to reward.

http://www.ncbi.nlm.nih.gov/pubmed/11306631

Certain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of two mildly pleasurable stimuli, orally delivered fruit juice and water. Using functional magnetic resonance imaging, the activity for rewarding stimuli in both the nucleus accumbens and medial orbitofrontal cortex was greatest when the stimuli were unpredictable. Moreover, the subjects' stated preference for either juice or water was not directly correlated with activity in reward regions but instead was correlated with activity in sensorimotor cortex. For pleasurable stimuli, these findings suggest that predictability modulates the response of human reward regions, and subjective preference can be dissociated from this response.

Pubmed ID: 11306631 RIS Download

Mesh terms: Adolescent | Adult | Brain | Brain Mapping | Computer Simulation | Corpus Striatum | Deglutition | Food Preferences | Frontal Lobe | Hippocampus | Humans | Intuition | Magnetic Resonance Imaging | Neural Networks (Computer) | Nucleus Accumbens | Prefrontal Cortex | Reward | Somatosensory Cortex | Stimulation, Chemical | Taste

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIDA NIH HHS, Id: K08 DA00367
  • Agency: NIDA NIH HHS, Id: R01 DA11723

SumsDB (Data, Activation Foci)

NeuroSynth (Data, Activation Foci)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.