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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

Science (New York, N.Y.) | Apr 20, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11292862

HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability. In the presence of oxygen, HIF is targeted for destruction by an E3 ubiquitin ligase containing the von Hippel-Lindau tumor suppressor protein (pVHL). We found that human pVHL binds to a short HIF-derived peptide when a conserved proline residue at the core of this peptide is hydroxylated. Because proline hydroxylation requires molecular oxygen and Fe(2+), this protein modification may play a key role in mammalian oxygen sensing.

Pubmed ID: 11292862 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Basic Helix-Loop-Helix Transcription Factors | Cell Hypoxia | Cell Line | Cobalt | Deferoxamine | Humans | Hydroxylation | Hydroxyproline | Ligases | Mass Spectrometry | Mice | Molecular Sequence Data | Oxygen | Protein Structure, Tertiary | Proteins | Recombinant Fusion Proteins | Trans-Activators | Transcription Factors | Tumor Cells, Cultured | Tumor Suppressor Proteins | Ubiquitin-Protein Ligases | Ubiquitins | Von Hippel-Lindau Tumor Suppressor Protein

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