Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Male-to-female sex reversal in mice lacking fibroblast growth factor 9.

Cell | Mar 23, 2001

Fgfs direct embryogenesis of several organs, including the lung, limb, and anterior pituitary. Here we report male-to-female sex reversal in mice lacking Fibroblast growth factor 9 (Fgf9), demonstrating a novel role for FGF signaling in testicular embryogenesis. Fgf9(-/-) mice also exhibit lung hypoplasia and die at birth. Reproductive system phenotypes range from testicular hypoplasia to complete sex reversal, with most Fgf9(-/-) XY reproductive systems appearing grossly female at birth. Fgf9 appears to act downstream of Sry to stimulate mesenchymal proliferation, mesonephric cell migration, and Sertoli cell differentiation in the embryonic testis. While Sry is found only in some mammals, Fgfs are highly conserved. Thus, Fgfs may function in sex determination and reproductive system development in many species.

Pubmed ID: 11290325 RIS Download

Mesh terms: Animals | Disorders of Sex Development | Embryonic and Fetal Development | Female | Fibroblast Growth Factor 9 | Fibroblast Growth Factors | Genitalia, Female | Genitalia, Male | High Mobility Group Proteins | Male | Mice | Mice, Knockout | Ovary | Restriction Mapping | SOX9 Transcription Factor | Sex Differentiation | Testis | Transcription Factors

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIGMS NIH HHS, Id: 5-T32-GM07200-25
  • Agency: NCI NIH HHS, Id: CA60673
  • Agency: NIGMS NIH HHS, Id: GM56757
  • Agency: NICHD NIH HHS, Id: HD33688
  • Agency: NICHD NIH HHS, Id: HD35692

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.