Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.

EMBO reports | Mar 29, 2001

http://www.ncbi.nlm.nih.gov/pubmed/11266364

Apoptosis signal-regulating kinase (ASK) 1 is activated in response to various cytotoxic stresses including TNF, Fas and reactive oxygen species (ROS) such as H(2)O(2), and activates c-Jun NH(2)-terminal kinase (JNK) and p38. However, the roles of JNK and p38 signaling pathways during apoptosis have been controversial. Here we show that by deleting ASK1 in mice, TNF- and H(2)O(2)-induced sustained activations of JNK and p38 are lost in ASK1(-/-) embryonic fibroblasts, and that ASK1(-/-) cells are resistant to TNF- and H(2)O(2)-induced apoptosis. TNF- but not Fas-induced apoptosis requires ROS-dependent activation of ASK1-JNK/p38 pathways. Thus, ASK1 is selectively required for TNF- and oxidative stress-induced sustained activations of JNK/p38 and apoptosis.

Pubmed ID: 11266364 RIS Download

Mesh terms: Animals | Antigens, CD95 | Apoptosis | Cells, Cultured | Enzyme Activation | Hydrogen Peroxide | JNK Mitogen-Activated Protein Kinases | MAP Kinase Kinase Kinase 5 | MAP Kinase Kinase Kinases | Mice | Mice, Knockout | Mitogen-Activated Protein Kinases | Signal Transduction | Tumor Necrosis Factor-alpha | p38 Mitogen-Activated Protein Kinases

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.