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The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.

The assembly of eukaryotic DNA into nucleosomes and derived higher order structures constitutes a barrier for transcription, replication and repair. A number of chromatin remodeling complexes, as well as histone acetylation, were shown to facilitate gene activation. To investigate the function of two closely related mammalian SWI/SNF complexes in vivo, we inactivated the murine SNF5/INI1 gene, a common subunit of these two complexes. Mice lacking SNF5 protein stop developing at the peri-implantation stage, showing that the SWI/SNF complex is essential for early development and viability of early embryonic cells. Furthermore, heterozygous mice develop nervous system and soft tissue sarcomas. In these tumors the wild-type allele was lost, providing further evidence that SNF5 functions as a tumor suppressor gene in certain cell types.

Pubmed ID: 11263494


  • Klochendler-Yeivin A
  • Fiette L
  • Barra J
  • Muchardt C
  • Babinet C
  • Yaniv M


EMBO reports

Publication Data

December 23, 2000

Associated Grants


Mesh Terms

  • Alleles
  • Animals
  • Apoptosis
  • Blastocyst
  • Blotting, Southern
  • Cell Death
  • Chromosomal Proteins, Non-Histone
  • Crosses, Genetic
  • DNA-Binding Proteins
  • Embryo, Mammalian
  • Exons
  • Female
  • Gene Expression Regulation
  • Gene Expression Regulation, Developmental
  • Genetic Predisposition to Disease
  • Genotype
  • Heterozygote
  • Immunohistochemistry
  • In Situ Nick-End Labeling
  • Lac Operon
  • Loss of Heterozygosity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Models, Genetic
  • Mutagenesis
  • Neoplasms
  • Polymerase Chain Reaction
  • Stem Cells
  • Time Factors
  • Transcription Factors
  • Transcription, Genetic
  • Transcriptional Activation
  • Vimentin
  • beta-Galactosidase