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BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase.

Activation of the mammalian mitogen-activated protein kinase known as BMK1 is required for growth factor-induced cell proliferation. To understand the mechanism by which BMK1 mediates this cellular response, this kinase was used as bait in a yeast two-hybrid-based library screening. Here, we report the identification of serum and glucocorticoid-inducible kinase (SGK) as a cellular protein that physically interacts with BMK1. During growth factor-induced cell stimulation, BMK1 activates SGK by phosphorylation at serine 78. This BMK1-mediated phosphorylation event is necessary for the activation of SGK and, more importantly, for cell proliferation induced by growth factors.

Pubmed ID: 11254654

Authors

  • Hayashi M
  • Tapping RI
  • Chao TH
  • Lo JF
  • King CC
  • Yang Y
  • Lee JD

Journal

The Journal of biological chemistry

Publication Data

March 23, 2001

Associated Grants

  • Agency: NCI NIH HHS, Id: CA79871

Mesh Terms

  • Cell Division
  • Enzyme Activation
  • Epidermal Growth Factor
  • Immediate-Early Proteins
  • Mitogen-Activated Protein Kinase 7
  • Mitogen-Activated Protein Kinases
  • Nuclear Proteins
  • Phosphorylation
  • Protein-Serine-Threonine Kinases