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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.

Pubmed ID: 11224536


  • Cai H
  • Wang Y
  • McCarthy D
  • Wen H
  • Borchelt DR
  • Price DL
  • Wong PC


Nature neuroscience

Publication Data

March 6, 2001

Associated Grants

  • Agency: NIA NIH HHS, Id: 1P01 AG14248
  • Agency: NIA NIH HHS, Id: 2P50 AG05146

Mesh Terms

  • Alzheimer Disease
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Animals
  • Aspartic Acid Endopeptidases
  • Cells, Cultured
  • Endopeptidases
  • Mice
  • Mice, Knockout
  • Neurons