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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.

Pubmed ID: 11224535


  • Luo Y
  • Bolon B
  • Kahn S
  • Bennett BD
  • Babu-Khan S
  • Denis P
  • Fan W
  • Kha H
  • Zhang J
  • Gong Y
  • Martin L
  • Louis JC
  • Yan Q
  • Richards WG
  • Citron M
  • Vassar R


Nature neuroscience

Publication Data

March 6, 2001

Associated Grants


Mesh Terms

  • Alzheimer Disease
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Animals
  • Aspartic Acid Endopeptidases
  • Central Nervous System
  • Endopeptidases
  • Mice
  • Mice, Knockout
  • Peripheral Nervous System
  • Phenotype
  • Plaque, Amyloid