Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development.

neuralized (neu) represents one of the strong neurogenic mutants in Drosophila. Mutants of this class display, among other phenotypes, a strong overcommitment to neural fates at the expense of epidermal fates. We analyzed the role of neu during adult development by using mutant clonal analysis, misexpression of wild-type and truncated forms of Neu, and examination of genetic interactions with N-pathway mutations. We find that neu is required cell-autonomously for lateral inhibition during peripheral neurogenesis and for multiple asymmetric cell divisions in the sensory lineage. In contrast, neu is apparently dispensable for other N-mediated processes, including lateral inhibition during wing vein development and wing margin induction. Misexpression of wild-type Neu causes defects in both peripheral neurogenesis and wing vein development, while a truncated form lacking the RING finger is further capable of inhibiting formation of the wing margin. In addition, the phenotypes produced by misexpression of wild-type and truncated Neu proteins are sensitive to the dosage of several N-pathway components. Finally, using epitope-tagged Neu proteins, we localize Neu to the plasma membrane and reveal a novel morphology to the sensory organ precursor cells of wing imaginal discs. Collectively, these data indicate a key role for neu in the reception of the lateral inhibitory signal during peripheral neurogenesis.

Pubmed ID: 11180964


  • Lai EC
  • Rubin GM


Developmental biology

Publication Data

March 1, 2001

Associated Grants


Mesh Terms

  • Animals
  • Drosophila
  • Drosophila Proteins
  • Larva
  • Ligases
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Peripheral Nerves
  • Receptors, Notch
  • Ubiquitin-Protein Ligases
  • Wing