Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein.

Neuron | Dec 22, 2000

http://www.ncbi.nlm.nih.gov/pubmed/11163260

Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dynein functions. Here we characterize NUDEL, a novel LIS1-interacting protein with sequence homology to gene products also implicated in nuclear distribution in fungi. Like LIS1, NUDEL is robustly expressed in brain, enriched at centrosomes and neuronal growth cones, and interacts with cytoplasmic dynein. Furthermore, NUDEL is a substrate of Cdk5, a kinase known to be critical during neuronal migration. Inhibition of Cdk5 modifies NUDEL distribution in neurons and affects neuritic morphology. Our findings point to cross-talk between two prominent pathways that regulate neuronal migration.

Pubmed ID: 11163260 RIS Download

Mesh terms: 1-Alkyl-2-acetylglycerophosphocholine Esterase | Axons | Base Sequence | Brain | Carrier Proteins | Cell Movement | Cells, Cultured | Centrosome | Conserved Sequence | Cyclin-Dependent Kinase 5 | Cyclin-Dependent Kinases | Cytoplasm | Dyneins | Enzyme Inhibitors | Fungal Proteins | Growth Cones | Humans | Male | Microtubule-Associated Proteins | Molecular Sequence Data | Neurons | Organ Specificity | Phosphoproteins | Sequence Homology, Amino Acid | Testis | Two-Hybrid System Techniques

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.