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The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.

Current biology : CB | Nov 16, 2000

http://www.ncbi.nlm.nih.gov/pubmed/11102810

Mammalian telomerase is essential for the maintenance of telomere length [1-5]. Its catalytic core comprises a reverse transcriptase component (TERT) and an RNA component. While the biochemical role of mammalian TERT is well established [6-11], it is unknown whether it is sufficient for telomere-length maintenance, chromosome stability or other cellular processes. Cells from mice in which the mTert gene had been disrupted showed progressive loss of telomere DNA, a phenotype similar to cells in which the gene encoding the telomerase RNA component (mTR) has been disrupted [1,12]. On prolonged growth, mTert-deficient embryonic stem (ES) cells exhibited genomic instability, aneuploidy and telomeric fusions. ES cells heterozygous for the mTert disruption also showed telomere attrition, a phenotype that differs from heterozygous mTR cells [12]. Thus, telomere maintenance in mammals is carried out by a single, limiting TERT.

Pubmed ID: 11102810 RIS Download

Mesh terms: Animals | Cell Line | DNA-Binding Proteins | Gene Targeting | Mice | RNA | Telomerase | Telomere

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Associated grants

  • Agency: NIA NIH HHS, Id: AG8422117

Mouse Genome Informatics (Data, Gene Annotation)

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