• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.

Caspases are cysteine proteases essential to apoptosis. We have identified two families of caspase-like proteins, Paracaspases (found in metazoans and Dictyostelium) and metacaspases (found in plants, fungi, and protozoa). Metazoan paracaspase prodomains contain a death domain and immunoglobulin domains. Several plant metacaspase prodomains contain zinc finger motifs resembling those in the plant hypersensitive response/cell death protein Isd-1. The human paracaspase prodomain binds Bcl10, a protein involved in the t(1;14)(p22;q32) translocation of mucosa-associated lymphoid tissue (MALT) lymphoma. Another MALT lymphoma translocation, t(11;18)(q21;q21), fuses the IAP-2 gene to the MLT1/MALT1 locus, which encodes the human paracaspase. We find that this fusion activates NF-kappaB and that the caspase domain is required for this function, since mutation of the conserved catalytic cysteine attenuates NF-kappaB activation.

Pubmed ID: 11090634

Authors

  • Uren AG
  • O'Rourke K
  • Aravind LA
  • Pisabarro MT
  • Seshagiri S
  • Koonin EV
  • Dixit VM

Journal

Molecular cell

Publication Data

October 9, 2000

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Caspases
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 14
  • Cloning, Molecular
  • Dictyostelium
  • Humans
  • Lymphoma, B-Cell, Marginal Zone
  • Molecular Sequence Data
  • Recombinant Proteins
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Transfection
  • Translocation, Genetic
  • Zinc Fingers