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A volumetric study of hippocampus and amygdala in depressed patients with subjective memory problems.

MRI was used to measure amygdalar and hippocampal volumes in 14 nondemented depressed patients who persistently complained of "memory" difficulties and in 14 control subjects. Mild neuropsychological impairment had been detected in 5 patients before the study but had later improved. The volume of the left amygdala was smaller in depressed subjects, and there was a trend for smaller left hippocampus in the 5 patients who had exhibited mild cognitive impairment. The authors conclude that subjective memory complaints in depressed patients do not translate into a clinical picture of dementia, but that abnormalities in the amygdala and hippocampus may be relevant in explaining affective and cognitive symptoms.

Pubmed ID: 11083167


  • von Gunten A
  • Fox NC
  • Cipolotti L
  • Ron MA


The Journal of neuropsychiatry and clinical neurosciences

Publication Data

February 14, 2000

Associated Grants

  • Agency: Multiple Sclerosis Society, Id: 491

Mesh Terms

  • Adult
  • Aged
  • Amygdala
  • Case-Control Studies
  • Depressive Disorder
  • Dominance, Cerebral
  • Female
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory Disorders
  • Middle Aged
  • Neuropsychological Tests
  • Psychiatric Status Rating Scales
  • Statistics, Nonparametric