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IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.

We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor relationships. Murine EVI27 was identified through its location at a common site of retroviral integration in BXH2 murine myeloid leukemias. IL-17Rh1 shows highest level expression in kidney with moderate expression in multiple other organs, whereas IL-17E mRNA was detected at very low levels in several peripheral tissues. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8.

Pubmed ID: 11058597 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Cell Line | Conserved Sequence | Female | Gene Library | Humans | Interleukin-17 | Interleukin-8 | Kidney | Leukemia, Experimental | Male | Mice | Molecular Sequence Data | NF-kappa B | Organ Specificity | Protein Isoforms | RNA, Messenger | Receptors, Interleukin | Receptors, Interleukin-17 | Recombinant Proteins | Sequence Alignment | Sequence Homology, Amino Acid | Transcription, Genetic | Transfection | Virus Integration