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IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.

We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor relationships. Murine EVI27 was identified through its location at a common site of retroviral integration in BXH2 murine myeloid leukemias. IL-17Rh1 shows highest level expression in kidney with moderate expression in multiple other organs, whereas IL-17E mRNA was detected at very low levels in several peripheral tissues. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8.

Pubmed ID: 11058597

Authors

  • Lee J
  • Ho WH
  • Maruoka M
  • Corpuz RT
  • Baldwin DT
  • Foster JS
  • Goddard AD
  • Yansura DG
  • Vandlen RL
  • Wood WI
  • Gurney AL

Journal

The Journal of biological chemistry

Publication Data

January 12, 2001

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Cell Line
  • Conserved Sequence
  • Female
  • Gene Library
  • Humans
  • Interleukin-17
  • Interleukin-8
  • Kidney
  • Leukemia, Experimental
  • Male
  • Mice
  • Molecular Sequence Data
  • NF-kappa B
  • Organ Specificity
  • Protein Isoforms
  • RNA, Messenger
  • Receptors, Interleukin
  • Receptors, Interleukin-17
  • Recombinant Proteins
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Transcription, Genetic
  • Transfection
  • Virus Integration