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Vasoregulation by the beta1 subunit of the calcium-activated potassium channel.

Small arteries exhibit tone, a partially contracted state that is an important determinant of blood pressure. In arterial smooth muscle cells, intracellular calcium paradoxically controls both contraction and relaxation. The mechanisms by which calcium can differentially regulate diverse physiological responses within a single cell remain unresolved. Calcium-dependent relaxation is mediated by local calcium release from the sarcoplasmic reticulum. These 'calcium sparks' activate calcium-dependent potassium (BK) channels comprised of alpha and beta1 subunits. Here we show that targeted deletion of the gene for the beta1 subunit leads to a decrease in the calcium sensitivity of BK channels, a reduction in functional coupling of calcium sparks to BK channel activation, and increases in arterial tone and blood pressure. The beta1 subunit of the BK channel, by tuning the channel's calcium sensitivity, is a key molecular component in translating calcium signals to the central physiological function of vasoregulation.

Pubmed ID: 11057658

Authors

  • Brenner R
  • Per├ęz GJ
  • Bonev AD
  • Eckman DM
  • Kosek JC
  • Wiler SW
  • Patterson AJ
  • Nelson MT
  • Aldrich RW

Journal

Nature

Publication Data

October 19, 2000

Associated Grants

None

Mesh Terms

  • Animals
  • Blood Pressure
  • Calcium Signaling
  • Cerebral Arteries
  • Female
  • Gene Targeting
  • Large-Conductance Calcium-Activated Potassium Channels
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Smooth, Vascular
  • Potassium Channels
  • Potassium Channels, Calcium-Activated
  • RNA, Messenger
  • Vasoconstriction
  • Vasodilation